2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

Phosphodiesterase (PDE)

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Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below. However, there are many other families of phosphodiesterases, including phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, as well as numerous less-well-characterized small-molecule phosphodiesterases. The cyclic nucleotide phosphodiesterases comprise a group of enzymes that degrade the phosphodiester bond in the second messenger molecules cAMP and cGMP. They regulate the localization, duration, and amplitude of cyclic nucleotide signaling within subcellular domains. PDEs are therefore important regulators ofsignal transduction mediated by these second messenger molecules.

Phosphodiesterase (PDE) Isoform Specific Products:

Phosphodiesterase (PDE) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-100615
    Revizinone
    		Inhibitor 98.31%
    Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.
    Revizinone
  • HY-15025S2
    Sildenafil-d3N-1
    		99.47%
    Sildenafil-d3-1 (UK-92480-d3-1) is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
    Sildenafil-d<sub>3</sub>N<sub>-1
  • HY-103267
    S32826 disodium
    		Inhibitor 98.85%
    S32826 disodium is a potent autotaxin inhibitor, with an IC50 of 8.8 nM. S32826 disodium shows similar inhibitory effects at various autotaxin isoforms (α, β and γ). S32826 disodium inhibits LPA release from adipocytes.
    S32826 disodium
  • HY-101693A
    Senazodan hydrochloride
    		Inhibitor 99.84%
    Senazodan (MCI 154) (hydrochloride), as a Ca2+ sensitiser, shows inhibition effect on PDE III.
    Senazodan hydrochloride
  • HY-U00208
    Prinoxodan
    		Inhibitor 99.83%
    Prinoxodan (RGW2938) is a phosphodiesterase inhibitor.
    Prinoxodan
  • HY-50865
    PDE-9 inhibitor
    		Inhibitor 99.79%
    PDE-9 inhibitor is useful for neurodegenerative diseases.
    PDE-9 inhibitor
  • HY-W003486
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
    		Inhibitor 99.16%
    5,7-Dichloropyrazolo[1,5-a]pyrimidine (fragment 5) is a pyrazolopyrimidine phosphodiesterase 10A (PDE10A) inhibitor (Ki=24 μM). 5,7-Dichloropyrazolo[1,5-a]pyrimidine can be used in the study of schizophrenia.
    5,7-Dichloropyrazolo[1,5-a]pyrimidine
  • HY-131100
    Homo Sildenafil
    		Inhibitor 99.32%
    Homo Sildenafil, an analog of Sildenafil, acts as a phosphodiesterase inhibitor.
    Homo Sildenafil
  • HY-15747A
    Deltarasin hydrochloride
    		Inhibitor 98.07%
    Deltarasin hydrochloride is an inhibitor of KRAS-PDEδinteraction with Kd of 38 nM for binding to purified PDEδ.
    Deltarasin hydrochloride
  • HY-A0165
    Tofisopam
    		Inhibitor 99.46%
    Tofisopam, a 2,3-benzodiazepine compound, is an orally active anxiolytic agent. Tofisopam can inhibit phosphodiesterase PDE isoenzyme activity, withIC50 values of 2.11 μM, 1.98 μM, 0.42 μM, and 0.92 μM for PDE-2A3, PDE-3A, PDE-4A1, and PDE-10A1, respectively. Tofisopam can be used for the study of anxiety.
    Tofisopam
  • HY-105092
    Tetomilast
    		Inhibitor ≥98.0%
    Tetomilast (OPC-6535) is a PDE4 inhibitor with potential for the research of inflammatory bowel disease (IBD) and chronic obstructive pulmonary disease (COPD).
    Tetomilast
  • HY-B0312S
    Dipyridamole-d20
    		Inhibitor ≥98.0%
    Dipyridamole-d20 is the deuterium labeled Dipyridamole. Dipyridamole is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
    Dipyridamole-d<sub>20</sub>
  • HY-131973
    PDE10A-IN-2 hydrochloride
    		Inhibitor 98.43%
    PDE10A-IN-2 hydrochloride is a potent, highly selective and orally active phosphodiesterase 10A (PDE10A) inhibitor with an IC50 of 2.8 nM. PDE10A-IN-2 hydrochloride shows selectivity of >3500-fold against other PDE subtypes. PDE10A-IN-2 hydrochloride can be used for pulmonary arterial hypertension (PAH) research.
    PDE10A-IN-2 hydrochloride
  • HY-B0204S1
    Pimobendan-d3
    		Inhibitor 99.43%
    Pimobendan-d3 (UD-CG115-d3) is deuterium labeled Pimobendan (HY-B0204). Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
    Pimobendan-d<sub>3</sub>
  • HY-152106B
    (±)-BAY-7081
    		Inhibitor 99.06%
    (±)-BAY-7081 is a racemate of BAY-7081 (HY-152106). BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC50 of 15 nM.
    (±)-BAY-7081
  • HY-122641
    Deltasonamide 1
    		Inhibitor 99.15%
    Deltasonamide 1 is a PDE6δ-KRas inhibitor. Deltasonamide 1 can inhibit PDE6δ-KRas with a KD of 203 pM. Deltasonamide 1 can be used for the research of tumors.
    Deltasonamide 1
  • HY-135711
    PDE8B-IN-1
    PDE8B-IN-1 is a selective inhibitor of phosphodiesterase 8B (PDE8B) with the activity of enhancing insulin secretion. PDE8B-IN-1 showed good efficacy in high-throughput screening and optimized its ligand efficiency through rapid deconstruction. PDE8B-IN-1 showed high target selectivity and good bioavailability in preclinical development, providing a basis for exploring its potential inhibitory use.
    PDE8B-IN-1
  • HY-122641A
    Deltasonamide 2
    		Inhibitor
    Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.
    Deltasonamide 2
  • HY-U00427
    PDE2/PDE10-IN-1
    		Inhibitor 99.88%
    PDE2/PDE10-IN-1 is a phosphodiesterase 2 (PDE2) and PDE10 inhibitor with IC50s of 29 and 480 nM, respectively.
    PDE2/PDE10-IN-1
  • HY-U00344A
    Theodrenaline hydrochloride
    		Inhibitor
    Theodrenaline hydrochloride is a cardiac stimulant, also acts as an anti-hypotensive agent together with Cafedrine.
    Theodrenaline hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Phosphodiesterase (PDE) Isoform Comparison

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